Abstract

BACKGROUND & OBJECTIVES: Systemic lupus erythmatosus (SLE) is an autoimmune disease and more than 100 auto antibodies have been detected in SLE. The present study was designed to determine the presence of anti-thyroid antibodies (ATA) in SLE patients. METHODS: It was a descriptive study and 42-SLE patients positive for anti-nuclear antibodies (ANA) and or anti-ds DNA (ds-DNA) antibodies were selected from Department of Rheumatology, Sheikh Zayed Hospital Lahore. Blood sample was collected and ATA was determined by indirect immunofluorescence technique. RESULTS: Thirty-nine (39) (92.9%) and 32 (76.2%) patients had ANA and ds-DNA antibodies respectively. On comparison, it was not statistically significant. Twenty- three (23) (54.76%) subjects had ATA and on comparison, it was not statistically significant. All the positive patients for ATA were females. CONCLUSION: Sensitivity of ANA and ds-DNA positive suspected SLE subjects to have ATA in their serum was 74%. About 55% of SLE patients were positive for ATA.

Keywords: Systemic lupus erythematosus · Anti-thyroid antibodies · Immunofluorescence

References

  1. 1.Abbas AK, Lichtman AH. Basic Immunology, Functions and Disorders of the Immune System. 2nd ed., Philadelphia: Elsevier Inc , 2004.
  2. 2.Hiepe F, Dorner T. Autoantibodies and antibody secreting cells. Rheumatol 2005;64:389–95.
  3. 3.Olsen NJ, Karp DR. Autoantibodies and SLE-the threshold for disease. N Rev Rheumatol 2014; 10,181–186.
  4. 4.Rutgers A, Heeringa P, Tervaert JC. The role of myeloperoxidase in pathogenesis of systemic High Percentage of ANA In SLE Patients, Afzal N et al p value 0.318 0.371 0.667 0.999 0.557 0.550 0.999 0.530 0.999 0.301 0.263 0.999 vasculitis. Clin Exp Rheumatol 2003;21:55-63.
  5. 5.Cooper GS, Dooley MA, Treadwell EL, Clair EW, Parks CG, Gilkeson GS. Hormonal, environmental and infectious risk factors for developing systemic lupus erythematosus. Arth Rheumatol. 1998; 4110:171424.
  6. 6.D'Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet 2007; 3699561:587-96.
  7. 7.Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arth Rheumatol 2012; 648:2677-86.
  8. 8.Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med. 2005; 201:703–711
  9. 9.Rahman A. Autoantibodies, lupus and the science of sabotage. Rheumatol. 2004; 43:1326-36.
  10. 10.Centers for Disease Control and Prevention. Systemic lupus erythematosus SLE or lupus. Available athttp:// www.cdc. gov/arthritis/basics/lupus.htm/#2. Accessed April 25, 2014.
  11. 11.Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006;155:308-18.
  12. 12.Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. PartI. Arth Rheumatol 2008; 581:15-25.
  13. 13.Bastian HM, Alarcón GS, Roseman JM, McGwin G Jr, Vilá LM, Fessler BJ, et al. LUMINA Study Group. 31 Original Article MAJMAAH JOURNAL HEALTH SCIENCE, 2015-vol 3, Issue 1 Systemic Lupus Erythematosus in the multiethnic US cohort LUMINA XL II: factors predicative of new or worsening proteinuria. Rheumatol 2006; 46: 683689.
  14. 14.Yaniv S, Alexander G, Marvin J, Fritzler Yehuda S. Autoantibody Explosion in Systemic Lupus Erythematosus : More than 100 Different Antibodies Found in SLE Patients. Seminar on Arthritis Rheumatology. Elsevier Inc, 2004; 34:501-537.
  15. 15.Innocencio RM, Romaldini JH, Ward LS. Thyroid autoantibodies in autoimmune diseases. Medicina. 2004; 64:277-30.
  16. 16.Kramer CK, Tourinho TF, de Castro WP, da Costa OM. Association between systemic lupus erythematosus, rheumatoid arthritis, hyperprolactinemia and thyroid autoantibodies. Arch Med R 2005; 361:54-8.
  17. 17.Pedersen IB, Knudsen N, Jorgensen T, Parrild H, Oversen L, Laurberg P. Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrin 2003;58:36-42.
  18. 18.Miller WF, Moore GF, Weintraub BD, Steinberg AD. Prevalence of thyroid disease and abnormal thyroid function testresults in patients with systemic lupus erythematosus. Arth Rheumatol 1987; 30:1124–1131.
  19. 19.Scofield RH. Autoimmune thyroid disease in systemic lupus erythematosus and Sjögren’ssyndrome, Clin Exp Rheumatol. 1996;14:321–30,
  20. 20.Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheumatol Dis. 2002; 61:70-72.
  21. 21.Maguire GA, Ginawi A, Lee J, Anita YN, Lim Graham W, Sally H, et al. Clinical utility of ANA measured by ELISA compared with ANA measured by immunofluorescence. Rheumatol 2009;48:10131014.
  22. 22.Kohno Y, Lee N, Naito K, Saito A, Hoshioka H, Niimi H, et al. Anti-thyroid peroxidase antibody activity in sera of patients with systemic lupus erythematous . Clin exp Immun 1989;75: 217-221.
  23. 23.Ezzat S, Sarti DA, Cain DR, Braunstein GD. Thyroid incidentatoma.Prevalence by population and ultrasonography. Arch Intern Med 1994;154:1838-40. High Percentage of ANA In SLE Patients, Afzal N et al
  24. 24.Gibson K, Goodemote P, Johnson S. FPIN’s clinical inquiries: antibody testing for systemic lupus erythematosus. Am Fam Physician. 2011; 84:14071409.
  25. 25.Gill JM, Quisel AM, Rocca PV, Walters DT. Diagnosis of systemic lupus erythematosus. Amirican Family Physician 2003;68:2179-2187.
  26. 26.Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P, Moutsopoulos HM. Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases Annals of Rheumotological Diseases 2004;63:1159-1161.
  27. 27.El-saadanya H, Elkhalika MA, Moustafab T, El barc EA. Thyroid dysfunction in systemic lupus erythematosus and rheumatoid arthritis: Its impact as a cardiovascular risk factor. The Egyptian rheumatologist 2014;36:7178.
  28. 28.Magaro M, Zoli A, Altomonte L, Mirone L, La Sala L, Barini A, et al. The association of silent thyroiditis with active systemic lupus erythematosus. Clinical and Experimental Rheumatology 1992;101:67-70.
  29. 29.Akbarian M, Soleymani H, Gharibdoost F, Nadji A, Jamshidi A, Shahram F, et al. Isolated Hematuria in SLE Patients and Its Association with Proteinuria,Urinary Cast and SLE Disease Activity. Acta Medica Iranica 2009;471: 5-8.
  30. 30.Christopher SL, Siedner M, Janice Lin Haas M, Parekh H, Petri M, Derek M. Fine Renal Biopsy in Lupus Patients with Low Levels of Proteinuria. Journal of Rheumatology 2006 ; 34:332–5.
  31. 31.Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, et al. Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus. Medicine Baltimore 1993;72:113-24.
  32. 32.Boddaert J, Huong DL, Amoura Z, Wechsler B, Godeau P, Piette JC. Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature. Medicine Baltimore 2004;836:348-59. 32
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