Abstract
Background and Aim: Over the Counter (OTC) medication usually used for the management of minor illness and they are available for the patients and can be obtained from the community pharmacies. The most common OTC analgesics that were associated with dependence are those capable of causing tolerance. OTC analgesics are generally non-harmful if used appropriately. The objectives of this study are to measure the prevalence and determine the pattern of using OTC analgesics among Al-Madinah population, and to assess their awareness and attitude regarding the related side effects and dependence. Methods: Cross-sectional study focused on Al-Madinah city, Saudi Arabia, from February 2019 to Augusts 2019, by using validated modified questionnaire distributed by using web-based link. The sample size was 600 participants. Data was analyzed by SPSS. Results: The prevalence of analgesics usage during the past 6 months was 85.8% (95% CI, 83% - 88.7%). The most common type of analgesics was paracetamol and Ibuprofen. Awareness regarding the side effects of OTC analgesics was high (61.8%) while the awareness regarding potential risk of dependence was 44.2%. The most common causes of taking OTC analgesics were headache and toothache, while the most common source of information was self-knowledge, whereas stomach ache was the most common side effect from OTC analgesics. Conclusions: Even though most of the general population in this study have sufficient knowledge about the side effects of OTC analgesics and that it may cause dependence or addiction, however, OTC analgesic usage of the general population is highly prevalent.
Keywords: Over the Counter · Medication · Analgesics · Awareness · side effects · dependence · General population
References
- 1.Mahrous MS. Frequency of use of non-prescribed medication among population sample from Al Madina City and its impact on quality of care in Saudi Arabia. Int J Health Sci (Qassim). 2018;12(5):3–9.
- 2.Nielsen S, Cameron J, Pahoki S. Over the Counter Codeine Dependence. 2010;1–76.
- 3.Hughes JR, Pillitteri JL, Callas PW, Callahan R, Kenny M. Misuse of and dependence on over-the-counter nicotine gum in a volunteer sample. Nicotine Tob Res. 2004;6(1):79–84.
- 4.Gossop M, Darke S, Griffiths P, Handio J, Powis B, Hall W et al. The Severity of Dependence Scale (SDS): psychometric properties of the SDS in English and Australian samples of heroin, cocaine and amphetamine users. Addiction. 1995;90(5):607–14.
- 5.WHO. World Health Organization. Lexicon of Alcohol and Drug Terms. 1994. p. 69.
- 6.Pineles LL, Parente R. Using the theory of planned behavior to predict self-medication with over-the-counter analgesics. J Health Psychol. 2013;18(12):1540–9.
- 7.Diener HC, Schneider R, Aicher B. Per-capita consumption of analgesics: A nine-country survey over 20 years. J Headache Pain. 2008;9(4):225–31.
- 8.McGettigan P, Henry D. Use of Non-Steroidal Anti-Inflammatory Drugs That Elevate Cardiovascular Risk: An Examination of Sales and Essential Medicines Lists in Low-, Middle-, and High-Income Countries. PLoS Med. 2013;10(2).
- 9.Lanas A, Ferrandez A. Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly. Drugs and Aging. 2007;24(2):121–31.
- 10.Manthripragada AD, Zhou EH, Budnitz DS, Lovegrove MC, Willy ME. Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States. Pharmacoepidemiol Drug Saf. 78 Majmaah Journal of Health Sciences ,Vol. 9, Issue 1, January - 2021, Jumadi ulAwwal - 1442 Practice andAwareness of the General PopulationAbout Common Over the CounterAnalgesics Dependence and Side Effects inAl-Madinah, SaudiArabia 2011;20(8):819-26.
- 11.Van Den Anker JN. Optimising the management of fever and pain in children. Int J Clin Pract. 2013;67(SUPPL. 178):26–32.
- 12.Victoria D of HS, MEDICINEWISE N. Medications - non-steroidal anti-inflammatory drugs. Better Health Channel. p. 1–4.
- 13.KD Rainsford. Anti-inflammatory drugs in the 21st century. - PubMed - NCBI. Subcell Biochem.2007.
- 14.General Authority for Statistics. stats.gov.sa/sites/default/files/ar-dmaps. (10).2010.
- 15.AlKhamees OA, AlNemer KA, Bin Maneea MW, AlSugair FA, AlEnizi BH, Alharf AA. Top 10 most used drugs in the Kingdom of Saudi Arabia 2010–2015. Saudi Pharm J. 2018;26(2):211–6.
- 16.Aljadhey H, Assiri GA, Mahmoud MA, Al-Aqeel S, Murray M. Self-medication in central Saudi Arabia: Community pharmacy consumers’ perspectives. Saudi Med J. 2015;36(3):328–34.
- 17.Fingleton NA, Watson MC, Duncan EM, Matheson C. Non-prescription medicine misuse, abuse and dependence: A cross-sectional survey of the UK general population. J Public Heal (United Kingdom). 2016;38(4):722–30.
- 18.Babakor SD, Al Ghamdi MM. Prevalence and determinants of over-thecounter analgesics usage among patients attending primary health care centers in Jeddah, Saudi Arabia. J Young Pharm. 2018;10(1):91–7.
- 19.Khalifeh MM, Moore ND, Salameh PR. Self-medication misuse in the Middle East: a systematic literature review. Pharmacol Res Perspect. 2017;5(4):1–13.
- 20.Albsoul-Younes AM, Jabateh SK, Abdel-Hafiz SM, Al-Safi SA. Awareness and frequency of potential side effects on nonsteroidal anti-inflammatory drugs among the Jordanian patient population. Saudi Med J. 2004;25(7):907—911.
- 21.Dale O, Borchgrevink PC, Fredheim OMS, Mahic M, Romundstad P, Skurtveit S. Prevalence of use of non-prescription analgesics in the Norwegian HUNT3 population: Impact of gender, age, exercise and prescription of opioids. BMC Public Health. 2015;15(1):1–9. Majmaah Journal of Health Sciences ,Vol. 9, Issue 1, January - 2021, Jumadi ulAwwal - 1442 79 Practice andAwareness of the General PopulationAbout Common Over the CounterAnalgesics Dependence and Side Effects inAl-Madinah, SaudiArabia
- 22.Salih S, Madkhali A, Al-Hazmi W, Al-Khaldy A, Moafa T, Al-Gahtani E, et al. Knowledge, attitude and practices on over the counter oral analgesics. Int J Med Dev Ctries. 2019;3(January):311–5.
- 23.Aashi M, Alghanmi H, Alhibshi R, Alsaati B, Aljohani N. Self-medication among medical student in King Abdul-Aziz University. Int J Res Med Sci. 2016;4(3):942–6.
- 24.IbrahimNKR,AlamoudiBM,Baamer WO, Al-Raddadi RM. Self-medication with analgesics among medical students and interns in King Abdulaziz University, Jeddah, Saudi Arabia. Pakistan J Med Sci. 2014;31(1):1–5.
- 25.Subhashini, Garla BK, Karuppaiah M, Taranath. Prevalence of Self-medication Practice among PeopleAttending Oral Health Outreach Programmes in Madurai East, Tamil Nadu. J Acad Adv Dent Res. 2017;222941121772910.
- 26.AlbasheerOB,MahfouzMS,Masmali BM, Ageeli RA, Majrashi AM, Hakami AN, et al. Self-medication practice among undergraduate medical students of a saudi tertiary institution. Trop J Pharm Res. 2016;15(10):2253–9.
- 27.Shivamurthy S, Manchukonda R, Gurappanavar D. Evaluation of self-medication patterns among under-graduate medical students of Adichunchanagiri institute of medical sciences, Karnataka, India: a cross-sectional questionnaire-based study. Int J Basic Clin Pharmacol. 2016;4(3):965–8.
- 28.Ira IJ. Present condition of self-medicationamonggeneralpopulationofComilla district, Bangladesh. Pharma Innov J. 2015;4(1):87–90.
Peer review
Peer reviewed by 2 reviewers, who chose to remain anonymous.